Sleep disorders commonly involve a deficiency of serotonin, GABA, and acetylcholine. Low levels of these neurotransmitters can also be associated with depression and anxiety.
Sentra PM is specially formulated to increase production of serotonin and acetylcholine in order to induce sleep and facilitate the important stage IV sleep.
Normal sleep cycles are carefully organized.
The initial rise in serotonin that initiates sleep leads to
the first REM cycle approximately 90 minutes after sleep is
initiated. This is termed REM latency. During the first REM
cycle, serotonin release is inhibited and acetylcholine release
increases. The first REM cycle is relatively short. Following
the first REM cycle, serotonin release increases and acetylcholine
falls. In normal sleep, this cycle recurs approximately 5 times
over the next 4 to 6 hours. Each REM episode progressively increases
until the last cycle where the REM episode may last as long
as 30 minutes. Each cycle is associated with release of the
associated neurotransmitterﾑREM sleep with acetylcholine and
non-REM sleep with serotonin.
Disruption of these normal cycles is associated
with a series of disorders including insomnia, sleep apnea,
snoring, narcolepsy, daytime sleepiness, daytime lack of concentration,
loss of memory, depression, and fatigue.
◆Indications
for Use
1. Difficulty in falling asleep
2. Difficulty in staying asleep
3. Waking up feeling unrefreshed
4. Snoring
1. 入眠障害
2. 異常覚醒
3. 不快な目覚め
4. イビキをかく
◆Dosing:
就寝時に1〜2カプセル。夜間に目が覚めたときにはもう一度服用しても構いません。
One or two capsules at bedtime according to response. An additional dose may be taken if awakened during the night.
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